OUR APPROACH 

Taking the journey towards comprehensive treatment of liver disease

 
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“We aim to leverage our cross-border culture to rapidly and efficiently deliver new therapies for to patients suffering from liver disease in China and across the globe.”  

Erin Quirk, M.D.
Chief Medical Officer

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THE TERNS DIFFERENCE

Leveraging an internal drug discovery engine, as well as strategically in-licensed compounds, Terns is developing a portfolio of therapies for the treatment of chronic liver diseases like non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD).

We are focused on rational combination strategies, targeting the spectrum of chronic liver disease progression, from steatosis to inflammation of the liver, fibrosis and cirrhosis.

 
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TERNS China:
There is a staggering need for new therapies in China.

Liver disease is a growing global health burden, particularly for the Chinese population. Our best-in-class drug development team in Shanghai is leading the new wave of NASH innovation in China. We leverage an increasingly flexible regulatory environment, enhanced R&D capabilities and world-class data technology to advance new therapeutics for Chinese patients living with liver disease.

 

NASH STRATEGY:
Our portfolio covers the full spectrum of chronic liver disease progression - from non-alcoholic fatty liver disease (NAFLD) and steatosis into non-alcoholic steatohepatitis (NASH): inflammation of the liver and fibrosis.

Research suggests farnesoid X receptor (FXR) agonists like TERN-101 will be the backbone of future combination treatments for NASH. Its broad pleiotropic effect across all stages of disease make it suitable as a primary treatment option. At every stage of disease, there will likely be a need for combination therapy and we are investigating new treatment options for each. This approach differentiates Terns from the many companies developing one or two assets against NAFLD and NASH.